C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01) C07D 207/12 (2006.01) C07D 211/22 (2006.01) C07D 211/26 (2006.01) C07D 211/44 (2006.01) C07D 211/58 (2006.01) C07D 211/62 (2006.01) C07D 241/06 (2006.01) C07D 243/08 (2006.01) C07D 279/12 (2006.01) C07D 295/20 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2703290
The present invention relates to new non-peptide derivatives of formula (1), wherein R1 -R5, Q and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
Cette invention se rapporte à de nouveaux dérivés non peptidiques de formule (I), dans laquelle R1-R5, Q et Z sont tels que définis dans les revendications, et à leurs antipodes optiques ou racémates et/ou sels et/ou hydrates et/ou solvates, qui sont des antagonistes sélectifs de la bradykinine du type B1, ainsi qu'à des procédés de production de ces composés, à des compositions pharmacologiques les contenant et à leur utilisation en traitement ou en prévention de la douleur et des affections inflammatoires. (I)
Beke Gyula
Bozo Eva
Farkas Sandor
Hornok Katalin
Keseru Gyorgy
Fetherstonhaugh & Co.
Richter Gedeon Nyrt.
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