C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C12N 15/11 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2348823
The invention relates to a positively charged oligomeric conjugate, containing an oligomer with a polymerization degree (PD) from 5 to 50, preferably 10 to 40 and more preferably 20, formed from monomeric components having free NH3+ in a number equal to or higher than 50 % of the polymerization degree. In particular, the invention provides new oligomeric conjugates of histidylated oligolysine liable to allow the transfer of oligonucleotides, peptides and oligosides into cells.
L'invention se rapporte à un conjugué oligomère chargé positivement, contenant un oligomère ayant un degré de polymérisation (PD) compris entre 5 et 50, compris de préférence entre 10 et 40 et idéalement égal à 20. Ce conjugué est formé de composants monomères comportant des ions NH¿3??+¿ libres en nombre supérieur ou égal à 50 % du degré de polymérisation. L'invention se rapporte particulièrement à de nouveaux conjugués d'oligolysine histidylée, aptes à favoriser le transfert d'oligonucléotides, de peptides et d'oligosides dans des cellules.
Bello-Roufai Mahajoub
Midoux Patrick
Monsigny Michel
Pichon Chantal
Fetherstonhaugh & Co.
I.d.m. Immuno-Designed Molecules
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