New peptide derivatives

Details New peptide derivatives New peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07C 237/06 (2006.01) C07C 279/04 (2006.01) C07C 279/12 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2125175

The invention relates to new competitive inhibitors of thrombin, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as anticoagulants for prophylaxis and treatment of thrombo- embolic diseases according to formula (I) wherein A represents a methylene group, an ethylene group or a propylene group, which may be substituted or A represents -CH2-O-CH2-, -CH2-S-CH2-, -CH2-SO-CH2- , or A represents -CH2-O-, -CH2-S-, -CH2-SO-, with the heteroatom functionality in position 4, or n is an integer 2 to 6; and B represents -N(R6)-C(NH)-NH2, wherein R6 is H or a methyl group, or B represents -S-C(NH)-NH2, or -C(NH)- NH2. Further described is new use in syn- thesis of pharmaceutical compounds of a compound of formula (II).

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