New peptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/04 (2006.01) A61K 31/47 (2006.01) A61K 38/04 (2006.01) C07D 217/16 (2006.01) C07D 401/12 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/087 (2006.01) C07K 5/107 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2152380

Compounds of formula (I) as well as methods for their preparation, their pharma- ceutical preparations and their use. The com- pounds of formula (I) are useful in therapy, especially as analgesics and as immunosup- pressive agents. R3, R4, R5, R6 are all H or R4 and R5 are both H and R3 and R6 are both lower alkyl groups or R3, R5, R6 are all H and R4 is F, Cl, Br, OH, NH2 or NO2; R7 is C?O or CH2; R8 is H or a lower alkyl group; R9 is (II), wherein m is 0-2 or (III) or (IV) or (V) or (VI) or (VII) or (VIII) wherein R10 is H, F, Cl, Br or I and m is 0-2; R11 is OH, NH2 or (IX) wherein R12 is H, NO2, F, Cl, Br or I, m is 0-2, R13 is COOH, CONH2, CH2OH, or any additional amino acid or pep- tide segment, or R11 is (X) wherein R14 is COOH, CONH2, CH2OH, or any additional amino acid or peptide segment; with the ex- ceptions of the compounds wherein R1, R2, R3, R4, R5, R6 and R8 are all H, R7 is C?O and R9 is (XI) and R11 is Phe-OH, Phe-NH2, OH or NH2.

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