C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 14/775 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2137814
The invention relates to a protein or a peptide containing or constituted by a peptide derived from peptide 18A and presen- ting the following characteristics: it is coiled in the form of an alpha helix having 5 turns, each turn bearing 3.6 amino acid resi- dues; the diameter of said helix is from about 13 .ANG. to about 16 .ANG.; the distance separating two consecutive turns of said helix be- ing from about 4 .ANG. to about 6 .ANG.; the length of the helix being from about 10 .ANG. to about 30 .ANG.; it is amphipathic; with said peptide being such that: either the amino acid in position 4 is Glu or Asp, and/or the amino acid in position 6 is Glu or Asp, and/or the amino acid in position 8 is Lys or Arg, and/or the amino acid in position 11 is Glu or Asp. This protein can form complexes with phospholipids, with said complexes being useful for the treatment of cardiovascular diseases.
Brasseur Robert
Deleys Robert
Labeur Christine
Rosseneu Maryvonne
Fetherstonhaugh & Co.
N.v. Innogenetics S.a.
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