New peptides derivatives

Details New peptides derivatives New peptides derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 38/05 (2006.01) C07C 279/22 (2006.01)

Patent

CA 2163011

A compound of the general formula (I): A1 - A2 -NH-(CH2)n - NH-C(NH)-NH2, wherein n is an integer 2, 3, 4, 5, or 6; preferably 3 or 4; A1 represents a stuctural fragment of formulae (IIa), (IIb), (IIc), (IId) or (IIe); A2 represents a structural fragment (a), as well as processes for the preparation thereof, the use and the pharmaceutical formulations.

Composés de la formule générale (I): A<1> - A<2> -NH-(CH2)n - NH-C(NH)-NH2, dans laquelle n représente un entier compris entre 2 et 6 inclus; de préférence 3 ou 4; A<1> représente un fragment de structure répondant aux formules (IIa), (IIb), (IIc), (IId) ou (IIe); et A<2> représente le fragment de la structure (a). Des procédés de préparation de ces composés, leur utilisation et des formulations pharmaceutiques les contenant sont également décrits.

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