New peptides useful as dual caspase-2/-6 inhibitors and...

Details New peptides useful as dual caspase-2/-6 inhibitors and... New peptides useful as dual caspase-2/-6 inhibitors and...

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/08 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07K 7/06 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2589460

The invention relates to peptides having a core sequence selected in the group comprising: SEQ ID N~1: VDEAD, SEQ ID N~2: LDEGD, SEQ ID N~3: VDEGD, SEQ ID N~4: VDESD, SEQ ID N~5: LDEKD, SEQ ID N~6: FDESD, SEQ ID N~7: LDEAD, application as inhibitors of caspase-2 and/or -6 activity.

L'invention concerne des peptides comprenant une séquence de noyau sélectionnée dans le groupe constitué par: SEQ ID N°1: VDEAD, SEQ ID N°2: LDEGD, SEQ ID N°3: VDEGD, SEQ ID N°4: VDESD, SEQ ID N°5: LDEKD, SEQ ID N°6: FDESD, SEQ ID N°7: LDEAD. L'invention concerne également l'application de ces peptides comme inhibiteurs de l'activité de la caspase-2 et/ou -6.

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