C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/14 (2006.01) A61K 31/437 (2006.01) A61K 31/549 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 25/28 (2006.01) A61P 31/04 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2722938
The present invention relates to new compounds of the formula (I), (II), or (III)wherein R1, R2, R3, R4, R5 and W are as defined herein, and pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A.beta. amyloid disease, such as observed in Alzheimer's disease, infectious diseases, PAI-I related disease, and in the manufacture of medicaments for such treatment.
La présente invention concerne de nouveaux composés de formule (I), (II) ou (III) dans lesquelles R1, R2, R3, R4, R5 et W sont tels que définis dans la description, et des compositions pharmaceutiques les contenant, et leur utilisation dans le traitement des amyloses, en particulier lamylose Aß, telles quobservées dans la maladie dAlzheimer, des maladies infectieuses, une maladie liée au PAI-I, et dans la fabrication de médicaments destinés à ce traitement.
Almqvist Fredrik
Das Pralay
Sellstedt Magnus
Almqvist Fredrik
Fetherstonhaugh & Co.
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