A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/54 (2006.01) A61K 9/14 (2006.01) A61K 31/5415 (2006.01) A61K 47/26 (2006.01) A61K 47/38 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2301304
Pharmaceutical compositions containing enolic carboxamide type antiinflammatory agent meloxicam that exhibit improved wettability, aqueous solubility, dissolution behaviour over a broad range of pH, and that are prepared by crystal structure modification of the drug through dry or wet mechanical homogenization with two further components - one of them is selected from a group of oligo - and dissolution improving, or alkalizing agent. The application of the formulations according to the present invention results in an improved biovailability and effectiveness of meloxicam.
Compositions pharmaceutiques contenant un agent anti-inflammatoire de type carboxamide énolique, désigné meloxicam, présentant des caractéristiques améliorées de mouillabilité, de solubilité aqueuse, de comportement à la dissolution sur une plage importante de pH et dont la préparation consiste à modifier la structure cristalline du médicament par homogénéisation mécanique sèche ou humide avec deux constituants supplémentaires, dont l'un est sélectionné dans un groupe oligo améliorant la dissolution ou consiste en un agent d'alcalinisation. Ces formulations permettent d'améliorer la biodisponibilité et l'efficacité de meloxicam.
Freudensprung Brigitte
Klokkers Karin
Struengmann Andreas
Hexal Ag
Macrae & Co.
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