New pharmaceutical compositions useful in the treatment of pain

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/20 (2006.01) A61K 9/14 (2006.01)

Patent

CA 2599386

There is provided pharmaceutical compositions for the treatment of pain comprising a pharmacologically-effective amount of an opioid analgesic, or a pharmaceutically-acceptable salt thereof; a pharmacologically-effective amount of an antiemetic compound, or a pharmaceutically-acceptable salt thereof; a bioadhesion and/or a mucoadhesion promoting agent; and carrier particles, wherein the active ingredients are presented in particulate form upon the surfaces of the carrier particles, which carrier particles are larger in size than the particles of the active ingredients; and the bioadhesion and/or mucoadhesion promoting agent is, at least in part, presented on the surfaces of the carrier particles.

L'invention concerne des compositions pharmaceutiques pour le traitement de la douleur, comprenant une dose pharmacologiquement acceptable d'un analgésique opioïde ou un sel pharmaceutiquement acceptable ce dernier ; une dose pharmacologiquement efficace d'un composé anti-émétique ou un sel pharmaceutiquement acceptable de dernier ; un agent favorisant la bioadhésion et/ou la mucoadhésion ; et des particules porteuse, les ingrédients actifs se présentant sous une forme particulaire sur les surfaces des particules porteuses, lesquelles sont de taille supérieure à celle des particules des ingrédients actifs ; et l'agent favorisant la bioadhésion et/ou la mucoadhésion étant, au moins en partie, présenté sur les surfaces des particules porteuses.

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