New pharmaceutical formulation

Details New pharmaceutical formulation New pharmaceutical formulation

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 9/24 (2006.01) A61K 9/50 (2006.01) A61K 31/557 (2006.01)

Patent

CA 2352613

This invention is related to new oral pharmaceutical dosage forms comprising a proton pump inhibitor, i.e. a H+, K+ -ATPase inhibitor, a gastric antisecretory prostaglandin analogue compound, and optionally an additional drug such as a calcium channel blocking agent, especially for use in the treatment and prophylaxis of gastrointestinal disorders. More specifically the invention is related to new dosage forms comprising omeprazole and misoprostol. The invention is also related to a combination of the three categories of drugs, i.e. the H+, K+ -ATPase inhibitor, the gastric antisecretory prostaglandin analogue, and the calcium channel blocking agent. Furthermore, the invention refers to a method for the manufacture of the described dosage forms and their use in medicine, as well as blister packs comprising these medicaments.

La présente invention concerne de nouvelles formes posologiques pharmaceutiques par voie orale comprenant un inhibiteur de pompe à protons, c.-à-d. un inhibiteur de H?+¿, K?+¿ ATPase, un composé analogue de prostaglandine antisécrétoire gastrique et éventuellement un médicament supplémentaire tel qu'un agent bloquant des canaux calciques, ces nouvelles formes posologiques étant spécialement destinées au traitement et à la prophylaxie de troubles gastro-intestinaux. Plus spécifiquement, l'invention concerne de nouvelles formes posologiques comprenant l'oméprazole et le misoprostol. L'invention concerne également une combinaison des trois catégories de médicaments, c.-à-d. l'inhibiteur de H?+¿, K?+¿ ATPase, l'analogue de prostaglandine antisécrétoire gastrique et l'agent bloquant des canaux calciques. En outre, l'invention concerne une méthode de fabrication des formes posologiques décrites et leur utilisation dans le domaine médical, ainsi que des plaquettes sous blister comprenant ces médicaments.

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