New pharmaceutically active compounds

Details New pharmaceutically active compounds New pharmaceutically active compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/50 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 475/00 (2006.01) C07D 475/02 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2265854

The present invention provides optionally substituted and/or annulated compounds of formula (I) wherein X, Y, Z and A is each independently carbon or nitrogen, and at least two of X, Y, Z and A are carbon; and pharmaceutically acceptable salts thereof with the proviso that: 3-(1H-Indol-3-yl)-1H- quinoxalin-2-one, 3-(2-Methyl-1H-indol-3-yl)-1H-quinoxalin-2-one, and 3-(1,2- Diphenyl-1H-indol-3-yl)-1H-quinoxalin-2-one are excluded from compounds of formula (I). The invention includes the use of compounds of formula (I) in medical therapy, particularly in the therapy of conditions requiring inhibition of protein kinase C.

Cette invention se rapporte à des composés éventuellement substitués et/ou annelés représentés par la formule (I), où X, Y, Z et A représentent chacun séparément carbone ou azote, et au moins deux des éléments X, Y, Z et A représentent carbone; et à des sels de ces composés acceptables sur le plan pharmaceutique, à la condition que: 3-(1H-indol-3-yl)-1H-quinoxalin-2-one, 3-(2-méthyle-1H-indol-3-yl)-1H-quinoxalin-2-one et 3-(1,2-diphényle-1H-indol-3-yl)-1H-quinoxalin-2-one soient exclus des composés de la formule (I). Cette invention concerne l'utilisation des composés de formule (I) en thérapie médicale, en particulier dans la thérapie d'états nécessitant une inhibition de la protéine-kinase C.

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