New phenyl-(4-phenyl-pyrimidin-2-yl)-amines derivatives,...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/42 (2006.01) A61K 31/506 (2006.01) A61P 3/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2673532

The invention relates to products of the formula (I) in which : R is H or HaI; R2, R3 and R4 are selected from H, HaI, CN, CONH2, CONHaIk, CON(alk)2, alkyl and alkoxy optionally substituted by HaI, CN, CONH2, CONHaIk, CON(alk)2, OH or 0CH3, with one or two of R2, R3 and R4 representing H or R2, R3 and R4 all representing methoxy; z is S02 or CO; and N(D) (W) is such as W is -cycle (Y) and D is H, cycloalkyl, alkyl, alkenyl, alkynyl, optionally substituted; cycle (Y) with Y is 0, S So, S02, NRlO, C=O, CF2, CH-0R8 or CH-NR8R9; or W and D form together with N a cycle (N) substituted by R1 and R6 so that, e.g., R1 is -X1-R7 with X1 being -(CH2)m- and R6 being H, OH, -CH20H, -CO- N-, -C02H, -C02alk; and R7 is heterocycloalkyl, aryl, heteroaryl, optionally substituted; with m = 1 - 3. The invention relates to said products under all their isomeric forms and to their salts, as drugs essentially used as IKK inhibitors.

L'invention concerne les produits de formule (I) : avec R représente H ou HaI; R2, R3 et R4 sont choisis parmi H, HaI, CN, CONH2, CONHaIk, CON(alk)2, alkyle et alcoxy éventuellement substitués par HaI, CN, CONH2, CONHaIk, CON(alk)2, OH ou 0CH3, avec ou deux de R2, R3 et R4 représentent H ou R2, R3 et R4 représentent tous trois méthoxy; z représente S02 ou CO; et N(D) (W) tel que : soit W représente -cycle (Y) et D représente H, cycloalkyle, alkyle, alkényle, alkynyle, éventuellement substitués; cycle (Y) avec Y représente 0, S So, S02, NRlO, C=O, CF2, CH-0R8 ou CH-NR8R9; soit W et D forme avec N un cycle (N) substitué par R1 et R6 tel que par exemple R1 représente -X1-R7 avec X1 représente -(CH2)m- et R6 représente H, OH, -CH20H, -CO- N-, -C02H, -C02alk; et R7 représente hétérocycloalkyle, aryle, hétéroaryle, éventuellement substitués; avec m=1- 3; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de IKK.

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