New piperidinyl-alkylamino-pyridazinone derivatives, a...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/50 (2006.01) A61P 25/22 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2480293

The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C1-4-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety.

L'invention concerne de nouveaux dérivés de pipéridinyl-alkylamino-pyridazinone représentés par la formule générale (I) (dans laquelle R représente hydrogène ou alkyle en C¿1-4?, X ou Y représente hydrogène et l'autre représente un groupe représenté par la formule générale (II), Hal représente halogène, et n égale 1 ou 2) ; des sels d'addition d'acide pharmaceutiquement acceptables de ces dérivés ; un procédé de préparation de ces dérivés ; et des compositions pharmaceutiques contenant ces composés. Les composés représentés par la formule générale ont un effet anxiolytique et sont utiles dans le traitement de l'anxiété.

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