New (poly)aminoalkylaminoalkylamide, alkyl-urea, or...

Details New (poly)aminoalkylaminoalkylamide, alkyl-urea, or... New (poly)aminoalkylaminoalkylamide, alkyl-urea, or...

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/36 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2733688

The present invention relates to new derivatives of epipodophyllotoxin 4- substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C1-4alkyl, - A represents CO(CH2)n or CONH(CH2)n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein.

La présente invention concerne des nouveaux dérivés d'épipodophyllotoxine à substitution 4 présentantune chaîne poly)aminoalkylaminoalkylamide éventuellement substituée, ou alkyle-urée ou alkyle- sulfonamide, un procédé permettant de les préparer ainsi que leur utilisation thérapeutique en tant qu'agent anticancéreux. Dans la formule (1): R représente hydrogène ou alkyle C1-4, A représente CO(CH2)n ou CONH(CH2)n, n = 2, 3, 4, ou 5, - R1 et R2 sont tels que définis dans la description.

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