New polymorphic forms of olanzapine

Details New polymorphic forms of olanzapine New polymorphic forms of olanzapine

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2395774

The invention provides three new polymorphic forms of 2-methyl-4-[4-methyl-1- piperazinyl]-10H-thieno[2,3b][1,5] benzodiazepine (Olanzapine) (Formula A), the process for preparing the new polymorphs and pharmaceutical compositions contain- ing the polymorphs. The new polymorphic forms of olanzapine are useful for the treatment of psychotic conditions, mild anxiety and gastrointestinal conditions.

La présente invention concerne trois nouvelles formes polymorphes de 2-méthyl-4-[4-méthyl-1- piperazinyl]-1OH-thiéno[2,3b][1,5] benzodiazépine (Olanzapine) (Formula A), le processus de préparation de ces nouveaux polymorphes et des compositions pharmaceutiques contenant ces polymorphes. Ces nouvelles formes polymorphes d'olanzapine conviennent pour le traitement de troubles psychotiques, de l'anxiété modérée et de troubles gastro-intestinaux.

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