C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/31 (2006.01) A61K 38/18 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C07K 14/485 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2709915
HER2 binding polypeptides comprising the amino acid sequence EX, RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO:1 ) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.
L'invention concerne des polypeptides de liaison à HER2 comprenant la séquence d'acides aminés EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ dans laquelle X1 en position 2 est M, I ou L, et X2 en position 39 est S ou C (SEQ ID NO:1 ). L'invention concerne, de plus, des peptides comprenant un environnement de chélation. L'invention concerne, en outre, des polypeptides radioétiquetés formés par des peptides comprenant un environnement de chélation et des radionucléides. L'invention concerne, de plus, des méthodes d'imagerie in vivo du corps d'un sujet mammifère souffrant ou susceptible de souffrir d'un cancer se caractérisant par la surexpression de HER2, consistant à administrer un polypeptide radioétiqueté puis à obtenir une image du corps à l'aide d'un instrument d'imagerie médicale, ainsi que des méthodes de traitement dudit cancer. L'invention concerne également l'utilisation d'un polypeptide radioétiqueté de ce type dans le diagnostic et le traitement du cancer se caractérisant par la surexpression de HER2. L'invention concerne enfin des acides nucléiques codant pour les polypeptides, des vecteurs d'expression comprenant les acides nucléiques et des cellules hôtes comprenant les vecteurs d'expression.
Abrahmsen Lars
Feldwisch Joachim
Herne Nina
Lendel Christofer
Tolmachev Vladimir
Affibody Ab
Fetherstonhaugh & Co.
LandOfFree
New polypeptides having affinity for her2 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with New polypeptides having affinity for her2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New polypeptides having affinity for her2 will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1459946