C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 7/00 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) C07J 5/00 (2006.01) C07J 9/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01)
Patent
CA 2251642
The invention discloses products with formula (I) in which: either R¿1? stands for halogen, hydroxyl, (C¿1?-C¿8?) alkyloxy or (C¿1?-C¿12?) acyloxy, and R¿2? represents halogen or hydrogen; or R¿1? and R¿2? together form a double bond, Z is selected from optionally substituted (C¿1?-C¿8?) alkylthio-, optionally susbtituted arylthio, (C¿1?-C¿8?) alkyloxy, halogen, cyano, mercapto, thiocyanato and (CH¿2?)¿0-1?-CO¿2?H, optionally esterified, Y stands for hydrogen or methyl and the dotted line in position 1-2 or 5-6 represents possibly a second bond. Also disclosed are the addition salts, manufacturing method and its intermediaries, and pharmaceutical compositions containing these substances.
L'invention a pour objet les produits de formule (I), dans laquelle soit R1 représente halogène, hydroxyle, (C1-C8)alkyloxy ou (C1-C12)acyloxy, et R2 représente halogène ou hydrogène, soit R1 et R2 forment ensemble une double liaison, Z est choisi parmi (C1-C8)alkylthio éventuellement substitué, arylthio éventuellement substitué, (C1-C8)alkyloxy, halogène, cyano, mercapto, thiocyanato et (CH2)0-1-CO2H, éventuellement estérifiés, Y représente hydrogène ou méthyle, le trait en pointillé en position 1-2 ou 5-6 représentant éventuellement une seconde liaison, ainsi que leurs sels d'addition, leur procédé de préparation, les intermédiaires de ce procédé et les compositions pharmaceutiques les renfermant.
Bhatnagar Neerja
Claussner Andre
Marchandeau Christian
Resche Rigon Michele
Teutsch Jean-Georges
Aventis Pharma S.a.
Hoechst Marion Roussel
Robic
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