A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/708 (2006.01) A61K 31/175 (2006.01) A61K 31/52 (2006.01)
Patent
CA 2163456
A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse-transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate- depleting drug to cells infected with such a virus.
Méthode d'inhibition de la réplication d'un virus à transcriptase inverse abrité par des cellules végétales ou animales. La méthode consiste à administrer à ces cellules un composé qui épuise les réserves intracellulaires de phosphate de désoxyribonucléoside dans des proportions suffisantes pour interdire la réplication dudit virus. L'hydroxyurée est l'un de ces composés appropriés. L'invention porte également sur une méthode permettant d'obtenir un ADN viral à transcriptase inverse incomplète en administrant à des cellules infectées par un tel virus une substance épuisant le phosphate de désoxyribonucléoside.
Cara Andrea
Gallo Robert C.
Gao Wen-Yi
Lori Franco
Departement Of Health And Human Services The Governement Of The United States Of America Represented By T
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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