New process

Details New process New process

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2276753

The present invention relates to a novel process for the synthesis of 5- methoxy-2- [[(4-methoxy-3, 5-dimethyl-2- pyridinyl)methyl] sulfinyl]-1<u>H</u>- benzimidazole, known under the generic name omeprazole. Moreover, the present invention also relates to manufacture of a pharmaceutical preparation thereof and its use in medicine. The novel process for the preparation of omeprazole, comprises the step of oxidizing 5-methoxy-2- [[(4-methoxy-3, 5-dimethyl-2- pyridinyl) methyl]thio]-1<u>H</u>- benzimidazole in an organic solvent with an oxidizing agent in the presence of a titanium complex and optionally in the presence of a base.

La présente invention concerne un procédé permettant la synthèse du 5-méthoxy-2- [[(4-méthoxy-3, 5-diméthyl-2- pyridinyl)méthyl] sulfinyl]-1<u>H</u>- benzimidazole, plus connu sous le nom générique d'oméprazole. L'invention concerne également la fabrication d'une préparation pharmaceutique à base d'un tel oméprazole et son utilisation médicale. Le procédé d'élaboration de l'oméprazole selon l'invention consiste d'abord à prendre un 5-méthoxy-2- [[(4-méthoxy-3, 5-diméthyl-2-pyridinyl) méthyl]thio]-1<u>H</u>- benzimidazole et à l'oxyder dans un solvant organique avec un agent oxydant en présence d'un complexe de titane et éventuellement en présence d'une base.

Affiliated with

Also associated with

Rating

New process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1596732