C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/755 (2006.01) C07K 14/78 (2006.01)
Patent
CA 2749902
There is described a chromatographic purification process that allows highly purified von Willebrand factor(vWF) and Fibronectin (Fn) to be obtained, starting from a biological fraction enriched in vWF and Fn and easily scaled up to industrial level. Chromatographic purification was obtained by a strong anionic exchange resin. The concentrates obtained have a high specific activity and, given the low content of contaminant proteins, are particularly suitable for therapeutic use.
La présente invention concerne un procédé de purification chromatographique qui permet d'obtenir le facteur Willebrand (vWF) et la fibronectine (Fn) avec une pureté élevée, à partir d'une fraction biologique enrichie en vWF et en Fn et qui est facilement extrapolé à l'échelle industrielle. La purification par chromatographie a été obtenue par une résine forte échangeuse d'anions. Les concentrats obtenus ont une activité spécifique élevée et, étant donnée la faible teneur en protéines contaminantes, sont particulièrement appropriés pour une utilisation thérapeutique.
Farina Claudio
Mori Filippo
Nardini Claudia
Nardini Ilaria
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kedrion S.p.a.
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