C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01)
Patent
CA 2679619
A process for preparing 3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one which process comprises the steps of: a) reacting 1 -phenylbutane-1,3-dione with ethyl 2-chloro-2-(hydroxyimino)acetate, b) subsequently reacting the product from step (a) with hydrazine or an hydrate thereof to yield 3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one, wherein step (b) is carried out on the mixture resulting from step (a) without isolating ethyl 4-benzoyl-5-methylisoxazole-3-carboxylate there from.
La présente invention concerne un procédé de préparation de 3-méthyl-4-phénylisoxazolo[3,4-d]pyridazin-7(6H)-un qui se compose des étapes suivantes : a) la réaction de 1 -phénylbutane-1,3-dione avec de l'éthyle 2-chloro-2-(hydroxyimino)acétate, b) la réaction suivante du produit de l'étape (a) avec de l'hydrazine ou un hydrate dérivé pour produire du 3-méthyl-4-phénylisoxazolo[3,4-d]pyridazine-7(6H)-un. L'étape (b) est réalisée sur le mélange résultant de l'étape (a) sans isoler l'éthyle 4-benzoyl-5-méthylisoxazole-3-carboxylate.
Marchueta Hereu Iolanda
Masia Xavier Serra
Almirall S.a.
Blake Cassels & Graydon Llp
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