New process for preparing an optically pure 2-morphinol...

Details New process for preparing an optically pure 2-morphinol... New process for preparing an optically pure 2-morphinol...

C - Chemistry, Metallurgy

07

D

C07D 265/32 (2006.01)

Patent

CA 2543575

The present invention relates to a process for preparing optically pure (+)- (2S, 3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates from a mixture of (+)-(2S, 3S)-2-(3- chlorophenyl)-3,5,5-trimethyl-2-morpholinol and (-)-(2R, 3R)-2-(3- chlorophenyl)-3,5,5-trimethyl-2-morpholinol. The process utilizes continuous chromatography, including techniques like Multi Column Chromatography (MCC), VARICOL, and Cyclojet.

La présente invention concerne un procédé permettant d'élaborer un (+)-(2S, 3S)-2-(3-chlorophényl)-3,5,5-triméthyl-2-morpholinol optiquement pur et certains de ses sels et solvates pharmaceutiquement admis. Ce traitement se fait à partir d'un mélange de (+)-(2S, 3S)-2-(3-chlorophényl)-3,5,5-triméthyl-2-morpholinol et de (-)-(2R, 3R)-2-(3-chlorophényl)-3,5,5-triméthyl-2-morpholinol. En l'occurrence, le procédé utilise la chromatographie en continue, avec des techniques telles que la chromatographie multi-colonne (MCC), le procédé VARICOL, et le dispositif Cyclojet.

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