New process for remifentanil synthesis

Details New process for remifentanil synthesis New process for remifentanil synthesis

C - Chemistry, Metallurgy

07

D

C07D 211/66 (2006.01)

Patent

CA 2670704

A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of a synthetic opiate or opioid compound by alkylating a substituted 4-piperidine in the presence of a base to form an intermediate that is further alkylated with an electrophilic alkylating agent and acylated to produce the compound.

L'invention concerne un procédé de synthèse du remifentanil ou carfentanil, ainsi que des intermédiaires à utiliser dans la préparation d'un composé opiacé ou opioïde synthétique par alkylation d'une 4-pipéridine substituée en présence d'une base pour former un intermédiaire qui est en outre alkylé avec un agent d'alkylation électrophile et acylé afin de produire le composé.

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