New process for synthesis of proton pump inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01)

Patent

CA 2606799

A process for preparation of rabeprazole sodium comprising oxidation of wet or dry rabeprazole sulphide with sodium hypohalite in water or a mixture of water and water miscible solvent using alkali metal hydroxide and catalyst is disclosed herein. The present invention also discloses process for preparation of rabeprazole sulphide.

Procédé d'élaboration de rabéprazole sodium : oxydation de sulfure de rabéprazole humide ou sec avec de l'hypohalite de sodium dans de l'eau ou un mélange d'eau et de solvant miscible dans l'eau en utilisant de l'hydroxyde de métal alcalin et un catalyseur. Egalement, procédé d'élaboration de sulfure de rabéprazole.

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