C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/06 (2006.01) A61K 31/55 (2006.01) C07C 217/54 (2006.01) C07D 223/16 (2006.01)
Patent
CA 2496712
Process for synthesizing formula (I) compounds: (see formula I) where R1 and R2, which are the same or different, each represent a linear or branched alkoxy group (C1-C8), or together with a carbon atom carrying them form a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring. Application involving the synthesis of ivabradine, its pharmaceutically acceptable acid addition salts, and its hydrates.
Procédé de synthèse des composés de formule (I) : (voir formule I) dans laquelle R1 et R2, identiques ou différents, représentent chacun un groupement alkoxy (C1-C8) linéaire ou ramifié, ou bien forment ensemble avec l'atome de carbone qui les porte un cycle 1,3-dioxane, 1,3-dioxolane ou 1,3-dioxépane. Application à la synthèse de l'ivabradine, de ses sels d'addition à un acide pharmaceutiquement acceptable et de ses hydrates.
Brigot Daniel
Lecouve Jean-Pierre
Lerestif Jean-Michel
Souvie Jean-Claude
Les Laboratoires Servier
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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