New process for the production of oxabispidines

Details New process for the production of oxabispidines New process for the production of oxabispidines

C - Chemistry, Metallurgy

07

D

C07D 245/02 (2006.01) C07D 498/08 (2006.01) A61K 31/5386 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2421776

There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4 and R41 to R46 have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula II, (II).

Cette invention concerne un procédé de fabrication d'un composé représenté par la formule I (I), [ou bien d'un sel ou d'un dérivé pharmaceutiquement acceptables de ce composé], dans laquelle A, B, G, R?1¿, R?2¿, R?3¿, R?4¿ et R?41¿ à R?46¿ ont la signification qui leur est attribuée dans le descriptif. Ce procédé comprend une cyclisation déshydratative du composé selon la formule II (II).

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