New process for the purification of aldehyde impurities

Details New process for the purification of aldehyde impurities New process for the purification of aldehyde impurities

C - Chemistry, Metallurgy

08

G

C08G 65/30 (2006.01)

Patent

CA 2377004

A novel process for the purification of poloxamers which contain aldehyde impurities, and particularly for the purification of the poloxamers named poloxamer 188 and poloxamer 407, which process includes dissolving the poloxamer(s) in a solvent which solvent may optionally contain an acid or a mixture of acids; if the solvent in which the poloxamer(s) has been dissolved is free from acid, acid is added; whereafter the aldehydes are removed.

L'invention concerne un nouveau procédé d'épuration de poloxamères qui contiennent des impuretés d'aldéhydes, et notamment d'épuration des poloxamères nommés poloxamère 188 et poloxamère 407. Ce procédé consiste à dissoudre le ou les poloxamère(s) dans un solvant qui peut éventuellement contenir un acide ou un mélange d'acides. Si le solvant dans lequel le/les poloxamère(s) ont été dissous est exempt d'acide, l'acide est ajouté. Ensuite, les aldéhydes sont enlevés.

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