New protein-polycation-conjugate

Details New protein-polycation-conjugate New protein-polycation-conjugate

C - Chemistry, Metallurgy

12

N

195/1.12, 530/15

C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/79 (2006.01) C07K 17/02 (2006.01) C12N 5/10 (2006.01) C12N 15/64 (2006.01)

Patent

CA 2012311

The invention relates to a system for transporting nucleic acids into the cell, which is effected by receptor-mediated endocytosis. Using a transferrin- polycation conjugate, a complex can be formed with the polyanionic nucleic acid. This complex is bound to the transferrin receptor, which is highly regulated in growing cells, and absorbed into the cell. Suitable nucleic acids include those which inhibit specific genes or the RNA function, such as antisense oligonucleotides or ribozymes or the genes coding for them. The invention further relates to a process for introducing nucleic acids into the cells, transferrin- polycation/nucleic acid complexes and pharmaceutical preparations containing them.

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