New proteins for use in human and animal staphylococcus...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/80 (2006.01) C07K 14/005 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2696864

The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO: 1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.

La présente invention porte sur un polypeptide appelé ply_pitti26 comprenant la séquence telle que représentée dans la SEQ ID NO:1 ainsi que sur les variants de ce polypeptide. De plus, la présente invention porte sur des acides nucléiques et des vecteurs codant pour ledit polypeptide et ses variants ainsi que sur des cellules hôtes comprenant ces acides nucléiques et/ou vecteurs. Enfin, la présente invention porte sur les utilisations dudit polypeptide, de ses variants, des séquences d'acide nucléique, des vecteurs et des cellules hôtes, en particulier pour le traitement ou la prophylaxie d'un sujet infecté par ou exposé à des Staphylococci.

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