A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 43/16 (2006.01) A61L 2/00 (2006.01) A61M 1/36 (2006.01) C07D 211/72 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2300382
Psoralen compound compositions are synthesized which have primary amino substitutions on the 3-, 4-, 5-, and 8-positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these psoralens result in the inactivation of pathogens which contain nucleic acid. The compounds show similar activity in test systems to 4' and 5' derivatives of psoralen useful for inactivation of pathogens in blood products. In addition to the psoralen compositions, the invention contemplates such inactivating methods using the new psoralens.
On a produit par synthèse des compositions de composés de psoralène qui comprennent des substitutions amine primaire sur les positions 3-, 4-, 5- et 8- du psoralène, mais qui autorisent cependant leur liaison à l'acide nucléique d'agents pathogènes. Les conditions de réaction qui photoactivent ces psoralènes ont pour effet d'inactiver les agents pathogènes contenant de l'acide nucléique. Les composés démontrent une activité similaire dans des systèmes de test aux dérivés 4' et 5' de psoralène utilisés pour inactiver des agents pathogènes dans des produits sanguins. Cette invention concerne également des procédés d'inactivation dans lesquels on utilise les nouveaux psoralènes.
Nerio Aileen
Wollowitz Susan
Borden Ladner Gervais Llp
Cerus Corporation
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