C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/14 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 3/04 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/10 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2671984
The present invention relates to compounds of general formula I wherein the groups and radicals B, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
La présente invention concerne des composés de formule générale (I) dans laquelle les groupes et radicaux B, W, X, Y, Z, R1, R2, sont tels que définis dans la revendication 1. L'invention concerne également des compositions pharmaceutiques contenant au moins un composé selon l'invention. Grâce à leur activité antagoniste du récepteur MCH, les compositions pharmaceutiques selon l'invention sont aptes au traitement de troubles métaboliques et/ou de troubles de l'alimentation, notamment l'obésité, la boulimie, l'anorexie, l'hyperphagie et le diabète.
Heckel Armin
Kley Joerg
Lehmann-Lintz Thorsten
Lotz Ralf
Mueller Stephan Georg
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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