New quinuclidine amide derivatives

Details New quinuclidine amide derivatives New quinuclidine amide derivatives

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/407 (2006.01) A61K 31/439 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) C07D 209/00 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2492535

New quinuclidine amide derivatives having the chemical structure of general formula (I) and pharmaceutically acceptable salts thereof including quaternary salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions 10 comprising them and their use in therapy as antagonists of M3 muscarinic receptors.

L'invention concerne de nouveaux dérivés de quinuclidine amide de structure chimique correspondant à la formule générale (I), ainsi que leurs sels pharmaceutiquement compatibles, y compris les sels quaternaires de formule (II). L'invention concerne en outre des procédés de préparation de ces dérivés, des compositions pharmaceutiques les renfermant et leur utilisation en thérapie, comme antagonistes de récepteurs muscariniques M3.

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