New ruthenium complexes as catalysts for metathesis reactions

Details New ruthenium complexes as catalysts for metathesis reactions New ruthenium complexes as catalysts for metathesis reactions

C - Chemistry, Metallurgy

07

C

C07C 235/06 (2006.01) A61K 38/05 (2006.01) A61P 31/12 (2006.01) C07C 235/16 (2006.01) C07D 295/185 (2006.01) C07D 487/04 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2719531

The invention relates to novel metathesis catalysts of the formula (I) a process for making the same and their use in metathesis reactions such as ring closing or cross metathesis. The invention further relates to a process for the manufacture of a macrocyclic compound of formula (VII) which have the potential to be useful as HCV protease inhibitors.

L'invention porte sur de nouveaux catalyseurs de métathèse représentés par la formule (I), sur un procédé permettant de les fabriquer et sur leur utilisation dans des réactions de métathèse telles que la fermeture de cycle par métathèse ou la métathèse croisée. L'invention porte en outre sur un procédé pour la fabrication d'un composé macrocyclique représenté par la formule (VII) qui est potentiellement utile comme inhibiteur de protéases du VHC.

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