C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 13/08 (2006.01)
Patent
CA 2398963
The present invention provides 4-amino-6,7-dimethoxy-2-(5- methanesulfonamido-1,2,3,4-tetrahy- droisoquinol-2-yl)-5-(2-pyridyl)quina- zoline mesylate of the formula (1) together with processes for preparing, and compositions containing it. The invention also relates to substantially pure anhydrous crystalline polymorphic forms of the free base. The compounds are particularly useful in the treatment of benign prostatic hyperplasia.
La présente invention concerne un mesylate de 4-amino-6,7-diméthoxy-2-(5-méthanesulfonamido-1,2,3,4-tétrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline de formule (1), des procédés de préparation de ce dernier et des compositions le contenant. L'invention se rapporte également à des formes polymorphes anhydres cristallines sensiblement pures de la base libre. Les composés de l'invention sont utilisés en particulier dans le traitement de l'hyperplasie bénigne de la prostate.
Basford Patricia Ann
Hodgson Paul Blaise
Pfizer Inc.
Smart & Biggar
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