New salt of thiazolidinedione and its polymorphs as...

Details New salt of thiazolidinedione and its polymorphs as... New salt of thiazolidinedione and its polymorphs as...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2436556

This invention relates to a new salt of 5-(4-{2-'(6-methoxy-pyrimidin-4-yl)- methyl-amino!-ethoxy}-benzyl)-thiazolidin-2,4-dione and its polymorphs which has high hypoglycemiant activity and which are therefore potentially useful in the treatment and/or prophylaxis of diabetes and/or other alterations or complications inherent to diabetes, such as hyyperglycemia or hyperlipidemia. This invention also relates to a method for making thereof.

L'invention concerne un sel de sodium de 5-(4-{2-'(6-méthoxy-pyrimidine-4-yle)-méthyle-amino!-éthoxy}-benzyle)-thiazolidine-2,4-dione et ses polymorphes qui présentent une activité hypoglycémiante élevée. Ce composé présente une utilité potentielle dans le traitement et/ou la prophylaxie du diabète et/ou d'autres altérations ou complications propres au diabète, comme l'hyperglycémie ou l'hyperlipidémie. La présente invention concerne aussi un procédé de fabrication de ce composé.

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