New salts

Details New salts New salts

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61P 21/00 (2006.01) A61P 29/00 (2006.01) A61P 31/06 (2006.01) A61P 31/08 (2006.01)

Patent

CA 2747558

This invention relates to a hydrochloride, malafe, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3- trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine- 3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.

L'invention porte sur des formes de sel chlorhydrate, malate, oxalate et tartrate d'acide 1-(4-{1-[(E)-4-cyclohexyl-3-trifluorométhyl-benzyloxyimino]-éthyl}-2-éthyl-benzyl)-azétidine-3-carboxylique (composé I), sur des compositions pharmaceutiques renfermant ce sel, sur des procédés pour former ce sel et sur son utilisation dans un traitement médical. De plus, la présente invention porte également sur de nouvelles formes polymorphes de chacun de ces sels, ainsi que sur des compositions pharmaceutiques renfermant ces formes polymorphes, sur des procédés pour les obtenir et sur leurs utilisations dans un traitement médical.

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