New silylated benzylamine derivatives and their salts;...

Details New silylated benzylamine derivatives and their salts;... New silylated benzylamine derivatives and their salts;...

C - Chemistry, Metallurgy

07

F

C07F 7/08 (2006.01) A61K 31/695 (2006.01)

Patent

CA 2167821

Novel silylated benzylamine derivatives, salts thereof, methods of manufacture and pharmaceutical compositions containing them are disclosed. These compounds have general formula (I) where R1-R6, X, Z, n and m have the meaning given in the description. The pure enantiomers and racemates of these compounds, salts, solvates (e.g. hydrates) and bioprecursors which are therapeutically acceptable are also disclosed.

La présente invention concerne de nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant. Ces composés répondent à la formule générale (I) dans laquelle R1 - R6, X, Z, n et m ont la signification donnée dans la description, les racémiques et les énantiomères purs de ces composés, les sels, solvates (par exemple, hydrates) et bioprécurseurs de ces composés acceptable pour l'usage thérapeutique.

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