New small molecule inhibitors of mdm2 and the uses thereof

Details New small molecule inhibitors of mdm2 and the uses thereof New small molecule inhibitors of mdm2 and the uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/10 (2006.01) A61K 31/395 (2006.01) A61K 31/407 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2661354

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

L'invention concerne de petites molécules qui agissent comme inhibiteurs de l'interaction entre p53 et MDM2. L'invention concerne également l'utilisation de ces composés pour inhiber la croissance cellulaire, induire la mort cellulaire, induire un arrêt du cycle cellulaire et/ou sensibiliser des cellules à un ou des agents supplémentaires.

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