New solid dose form of nanoparticulate naproxen

Details New solid dose form of nanoparticulate naproxen New solid dose form of nanoparticulate naproxen

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/46 (2006.01) A61K 31/19 (2006.01)

Patent

CA 2342309

Described are solid dose nanoparticulate naproxen formulations having high rates of dissolution. The solid dose nanoparticulate naproxen formulations can comprise an alkali compound, which functions to increase the dissolution rate of the naproxen following administration. Alternatively, the solid dose nanoparticulate naproxen formulation can comprise an alkali compound and an acidic compound, which can react together to form carbon dioxide. The formed carbon dioxide can also aid in increasing the dissolution rate of the naproxen following administration. Also described are solid dose nanoparticulate naproxen formulations having decreased concentration of a binder/disintegrant agent. Such compositions also provide an increased rate of dissolution of naproxen following administration.

La présente invention concerne des formulations nanoparticulaires de naproxène en dose solide caractérisées par des taux de dissolution élevés. Lesdites formulations peuvent renfermer un composé alkalin dont la fonction est d'accélérer le taux de dissolution après administration. En variante, la formulation nanoparticulaire de naproxène en dose solide peut renfermer un composé alcalin et un composé acide qui réagissent l'un avec l'autre pour donner du dioxyde de carbone. L'acide de carbone ainsi obtenu peut lui aussi accroître le taux de dissolution du naproxène après administration. L'invention porte également sur des formulations nanoparticulaires de naproxène en dose solide présentant une moindre concentration de liant/désintégrant. De telles compositions garantissent également un taux de dissolution accrue du naproxène après administration.

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