New spirotricyclic derivatives and their use as...

Details New spirotricyclic derivatives and their use as... New spirotricyclic derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 239/72 (2006.01) A61K 31/527 (2006.01) A61K 31/5377 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2441313

The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III), in which X1, X2, X3, X4, X, Y, Z, A and Z1 are as defined in the description, methods for preparing them and their use for the treatment of disorders for which therapy by a PDE7 inhibitor is relevant.

L'invention concerne des composés qui sont des inhibiteurs de la PDE7 et qui sont de formules (I), (II), (III) dans lesquelles X¿1?, X¿2?, X¿3?, X¿4?, X, Y, Z, A et Z?1¿ sont tels que définis dans le descritptif. L'invention se rapporte en outre à des méthodes relatives à leur préparation et à leur utilisation dans le traitement de troubles pouvant être traités de manière appropriée à l'aide de PDE7.

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