New stabilized galenic formulations comprising an acid...

A - Human Necessities – 61 – K

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A61K 31/4439 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 31/44 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2184842

New stable galenic formulations containing an acid-labile benzimidazol compound, and production process. Said formulations comprise a neutral nucleus on which is applied a layer containing the active ingredient and comprised of the benzimidazol compound having the general formula (I), a water-soluble polymer nnd non-alkaline reaction vehicles, and on which is applied a second isolating layer which comprises a water-soluble polymer, a pigment and talcum, and a last enteric layer which contains a polymor, a plastifier and talcum.

Nouvelles formulations galéniques stables contenant un composé benzimidazole acide-labile, et procédé de production. Lesdites formulations comprennent un noyau neutre sur lequel on applique une couche contenant l'ingrédient actif et constituée du composé de benzimidazole ayant la formule générale (I), un polymère hydrosoluble et des excipients de réaction non alcaline, couche sur laquelle on applique une deuxième couche isolante comprenant un polymère hydrosoluble, un pigment et du talc, et finalement une troisième couche entérique qui contient un polymère, un plastifiant et du talc.

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