New streptogramins and process for preparing streptogramins...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/52 (2006.01) A61K 38/15 (2006.01) C07C 229/36 (2006.01) C07C 229/42 (2006.01) C07C 233/15 (2006.01) C07C 233/25 (2006.01) C07C 323/60 (2006.01) C07C 323/63 (2006.01) C07D 295/155 (2006.01) C07K 7/06 (2006.01) C07K 11/02 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 15/76 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2193130

This invention concerns new compounds related to streptogramin group B, of general formula (I) and to a process for preparing streptogramins by mutasynthesis, using a microorganism mutated in such as a way as to alter the biosynthesis of at least one of the precursors of streptogramin group B. It also concerns new nucleotide sequences involved in the biosynthesis of these precursors and their uses.

La présente invention se rapporte à de nouveaux composés apparentés aux streptogramines du groupe B, de formule générale (I) et à un, procédé de préparation de streptogramines par mutasynthèse mettant en oeuvre un micro-organisme muté de manière à altérer la biosynthèse d'au moins un des précurseurs des streptogramines du groupe B. Elle concerne également des nouvelles séquences nucléotidiques impliquées dans la biosynthèse de ces précurseurs et leurs utilisations.

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