New substituted indolinones,their preparation and their use...

Details New substituted indolinones,their preparation and their use... New substituted indolinones,their preparation and their use...

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) A61K 31/40 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 209/48 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) A61K 31/403 (2006.01) A61K 31/4035 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01)

Patent

CA 2342622

The invention relates to novel substituted indolinones of general formula (I), wherein X and R1 to R5 have the meanings given in claim no.1, and to isomers and salts thereof with useful properties. The above compounds of general formula (I), wherein R1 represents a hydrogen atom, a C1-3-alkyl group or a pro-drug radical, have useful pharmacological properties, especially an inhibitory effect on various kinases, on viral cyclin and on receptor tyrosine kinases. The other compounds of general formula (I), wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or pro-drug radical, represent useful intermediate products for producing the above-mentioned compounds.

L'invention concerne de nouvelles indolinones substituées de la formule générale (I) où X et R¿1? à R¿5? ont la définition donnée dans la revendication 1, leurs isomères et leurs sels ayant de précieuses propriétés. Les composés susmentionnés de la formule générale (I) où R¿1? représente un atome d'hydrogène, un groupe alkyle C¿1-3? ou un reste prodrogue, ont de précieuses propriétés pharmacologiques et notamment un effet inhibiteur sur différentes kinases, sur la cycline virale et sur le récepteur tyrosine kinase. Les autres composés de la formule générale (I), où R¿1? ne représente ni un atome d'hydrogène, ni un groupe alkyle C¿1-3?, ni un reste prodrogue, sont de précieux produits intermédiaires pour la production des composés précédemment cités.

Affiliated with

Also associated with

Rating

New substituted indolinones,their preparation and their use... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New substituted indolinones,their preparation and their use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New substituted indolinones,their preparation and their use... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1642299