C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/496 (2006.01) A61K 31/517 (2006.01) A61K 31/551 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2395541
The present invention relates to substituted piperidines of general formula (see formula I) wherein A1, A2, R, R1 and R2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
L'invention concerne des pipéridines substituées de la formule générale (I) dans laquelle A<1>, A<2>, R et R<1> et R<2> sont définis comme dans la revendication 1. L'invention concerne également leurs tautomères, leurs diastéréomères, leurs énantiomères, leurs mélanges et leurs sels, en particulier leurs sels physiologiquement tolérables avec des acides inorganiques ou organiques ou des bases présentant des propriétés pharmacologiques précieuses, notamment des propriétés CGRP-antagonistes, des médicaments contenant ces composés, leur utilisation et des procédés permettant de les préparer.
Bauer Eckhart
Doods Henri
Dreyer Alexander
Eberlein Wolfgang
Hurnaus Rudolf
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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