C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01) C07D 207/26 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 211/56 (2006.01) C07D 211/62 (2006.01) C07D 211/76 (2006.01) C07D 213/38 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 233/54 (2006.01) C07D 239/04 (2006.01) C07D 239/42 (2006.01)
Patent
CA 2667285
The present invention relates to new sulfonamide derivatives of formula (I), wherein R1 -R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
La présente invention concerne de nouveaux dérivés sulfonamides de formule (I), dans laquelle R1 à R5 et Z sont tels que définis dans les revendications, ainsi que des antipodes optiques ou des racémates et/ou des sels et/ou des hydrates et/ou des solvates de ces dérivés, qui sont des antagonistes sélectifs de la bradykinine B1. L'invention concerne également des procédés de préparation de ces composés, des compositions pharmacologiques les contenant et leur utilisation dans le traitement ou la prévention d'états douloureux et inflammatoires.
Beke Gyula
Bozo Eva
Eles Janos
Farkas Sandor
Hornok Katalin
Fetherstonhaugh & Co.
Richter Gedeon Nyrt.
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