C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/73 (2006.01) A61K 39/02 (2006.01) C12N 1/21 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2263848
The present invention concerns a process for selecting new PR- or PL-operator sequences of lambdoid phages which, compared to wild-type sequences, have a different thermostability for the binding of a repressor. In addition, the invention discloses new mutated PR- or PL- operator sequences and their use for temperature-regulated expression of genes and for producing improved vaccines.
La présente invention concerne un procédé pour sélectionner de nouvelles séquences d'opérateurs P¿R? ou P¿L? constituées de phages lambdoïdes qui présentent une thermostabilité différente de celle des séquences de type sauvage, pour la fixation d'un répresseur. L'invention concerne en outre de nouvelles séquences d'opérateurs P¿R? ou P¿L? mutées, ainsi que leur utilisation pour l'expression génétique thermorégulée et pour la préparation de vaccins améliorés.
Jechlinger Wolfgang
Lubitz Werner
Szostak Michael
Witte Angela
Evax Technologies Gmbh Vaccine Development
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Prof. Dr. Werner Lubitz
LandOfFree
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