New taxane derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) A61K 31/337 (2006.01) A61K 31/4523 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 305/14 (2006.01)

Patent

CA 2302445

This invention relates to a taxane derivative represented by the following formula (1): (see formula (1) (wherein A represents a substituted piperazino or piperidino group, X represents an alkyl, pyridyl, thienyl, furyl, cycloalkyloxy or the like and Y represents H or trialkylsilyl) and also to a drug containing the same. This compound has high solubility in water and also has excellent antitumor activities.

L'invention concerne des dérivés de taxane de la formule générale (1) dans laquelle A représente pipérazino ou pipéridino substitué), X représente alkyle, pyridyle, thiényle, furyle, cycloalcoxy ou analogue; et Y représente H ou trialkylsilyle, ainsi que des médicaments les contenant. Ces composés sont hautement solubles dans l'eau et présentent une excellente activité antitumorale.

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