C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2704008
This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3- b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
La présente invention concerne des nouveaux composés tétracycliques qui peuvent être utilisés pour moduler un récepteur de l'histamine chez un individu. Dans un mode de réalisation, les composés sont des [4,3- b]indoles tétracycliques. L'invention concerne également des compositions pharmaceutiques comprenant les composés, ainsi que des procédés d'utilisation des composés dans diverses applications thérapeutiques, dont le traitement d'un trouble cognitif, d'un trouble psychotique, d'une affection induite par un neurotransmetteur et/ou d'une affection neuronale.
Bachurin Sergey Olegovich
Beznosko Bogdan Konstantinovich
Chakravarty Sarvajit
Dugar Sundeep
Grigoriev Vladimir Viktorovich
Borden Ladner Gervais Llp
Medivation Technologies Inc.
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