New tetrahydronaphthalene derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 207/16 (2006.01) A61K 31/215 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) C07C 235/78 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2126198

2126198 9312070 PCTABS00022 The invention relates to new tetrahydronaphthalene derivatives of general formula (I) wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, a C1-4 alkoxycarbonylalkyl or benzyl group, or R1 and R2 together represent a group of formula -(CH2)3-, R3 represents a hydroxy, C1-4 alkoxy or benzyloxy group or a group of general formula (A), wherein R5 represents a C1-4 alkyl group, and n represents 0, 1, 2, 3 or 4, and their pharmaceutically acceptable salts, furthermore to a process for preparing the same. The compounds exert valuable antiulcer and cytoprotective activity in mammals including men.

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